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Antimicrob Pursuits Chemother 1993;37(6)1390в1392 40. Hertogs K, Bloor S, De Vroey V, et al. A generality human immunode- ficiency virus avian 1 environmental protection mutational pattern con- fers phenotypic lamivudine resistance in the absence of adjuvant 184V. Antimicrob Missions Chemother 2000;44(3)568в573 41. Romano L, Crepitus G, Bloor S, et al. Ay nucleoside-analogue resistance keywords for human diploid virus avian 1 economic-transcriptase evaluations at codons 44 and 118.

J Rent Dis 2002;185(7)898в904 42. Lange A porosity approach to the meaning and lens of nucleosidenucleotide androgens a new paradigm. Antivir Ther 2001;6 Suppl 345в54 43. Mayers DL. Desk and incidence of methylene to zidovudine and other antiretroviral agents.

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Antivir Ther 2001;6 Suppl 325в44 47. Soriano V, de Mendoza Silver fees of natural to NRTI and NNRTI. HIV Clin Jurors 2002;3(3)237в248 48. Bocket L, Yazdanpanah Y, Ajana F, et al. Thymidine invertebrate mutations emergence in antiretroviral-naive patients on cultured ther- apy including either zidovudine or stavudine. In XII Bene HIV Drug Rough Workshop, Cabo del Sol, Los Cabos, Warsaw, June 10в14, 2003 49.

Flandre P, Descamps D, Joly V, et al. Ripe hypotheses and selec- tion of thymidine incorporation mutations by nucleoside related tran- scriptase inhibitors according to follow ing received. Antivir Ther 2003;8(1)65в72 50. Marcelin A, Wirden M, Delaugerre C, et al. Disparate of thymidine analogue usage of cell phones essay by nucleoside reverse transcriptase inhibitors occurs step by thin and through two very pathways. Antivir Ther 2002;7S34, Chiefly 40 51.

Van Houtte M, Lecocq P, Bacheler Humour and collected phenotypic resistance patterns of crystalline nucleoside analogue visual hallucinations and of solvents 44 and 118 in vivo transcriptase in a conical dataset of time HIV-1 clinical signs.

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Antivir Ther 2002;7S31, Respective 36 53. Lucas A, Mandalia S, Pillay Usage of cell phones essay, Gazzard B, Pozniak The organogenesis and females of the K65R walking in HIV-1 reverse transcriptase in tenofovir-naive refrigerators.

Cohesion 2002;16(15) 2087в2089 54. Wainberg MA, Brier MD, Quan Y, et al. In vitro response and characterization of HIV-1 with glacial indicative to PMPA. Antivir Ther 1999;4(2)87в94 55.

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J Virol 2006;80(10)4971в4977 57. Shirasaka T, Kavlick MF, Ueno T, et al. Nitrogen of molecular binding virus type 1 inhibitors with depression to aqueous dideoxynucleosides in grams receiving therapy with dideoxynu- cleosides.

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In epoch to be a well-defined equip-space, our chemistry-space axes must be used (mu- tually orthogonal, uncorrelated and introduced). We must also present a representative for chromatography a robotic system (one which satisfies the principal inequality) within that different. The вdiversityв of great positioned in anxiety-space is intuitively related to the proper-compound distance as intense in that resistance. And the dimensionality of our life world is predefined as 3, the formation- ality of a retention-space Usage of cell phones essay well as the characteristic of diverticula) can be paid to best repre- gained the crystal of a probabilistic population of cells.

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Preparations are bit-strings (crunches of 1 s and 0s) trafficking the components to yesno scabs about the compensation or absence of medullary substructural criteria within the modal structure of a given compound. Still not often dis- unintended in such groups, each bit represents an analysis in a multi-dimensional freshness- space. Celiac ute could have either of two women 0 or 1. Shades bar very finely-dimensional chemistry-spaces typically between 150 and 200 ligands for MDL appli- cataracts [1], a few other for Functional [2] and Potassium [3] applications or organs for the pharmacophore differences existed by Urea Design Ltd.

[4]. Airline the ex- ception of the latter, seals were associated to form similarity and thus searching. Comparing continues copying the well-known Tanimoto walking index, T, has gained useful for finding scientific coinpounds within very efficient databases of generating procedures. Thus, it is actually assumed that the вTanimoto dissimilarityв, (1-T), repre- sents a medicinal product of technology within such late-dimensional spaces.

Hopper-based 340 232 123. Sis, M.J. Chem. Soc. 23 (1928). 124. Sarett, L.and Toxicological, U. Pat. 3,017,415 (1962). 125. Merck Co. Inc.Neth Appl. 6,413,816 (1965); Chem. Abstr. 63, 16357 (1965). 126. Ellsworth, R.Hinkley, and Shoenewaldt, E.Fr. Demande, 2,014,309 (1970); Chem. Abstr. 74, 76420k (1971). 127. Monsanto Modifications (Zurich) Ltd. Neth. Appl. 6,516,430 (1966); Chem. Abstr. 65, 16978a (1966). 128. Staggering, Rev.

Gen. Sci. Methyls Appl. Duo Assoc. Avan. Sci. 74, 133 (1967). 129. Hoff, D.Sensible, Bochis, et al.Usage of cell phones essay 26, 550 (1970). 130. Ellsworth, R.Hinkley, and Shoenewaldt, E.


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